MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Dronedarone Hydrochloride

CAS No. : 141625-93-6

MCE 站：Dronedarone Hydrochloride

产品活性：Dronedarone Hydrochloride 是一种非碘化胺碘酮衍生物, 可抑制Na⁺, K⁺ and Ca²⁺的电流。

研究领域：Membrane Transporter/Ion Channel  |  Autophagy

作用靶点：Potassium Channel  |  Autophagy

In Vitro: Dronedarone (SR-33589) is a multichannel blocker for atrial fibrillation . It is a potent inhibitor of the acetylcholine-activated K⁺ current from atrial and sinoatrial nodal tissue, and inhibits the rapid delayed rectifier more potently than slow and inward rectifier K+ currents and inhibits L-type calcium current. Under whole-cell patch clamp, it blocks I_Kr (IC₅₀=3 μM) and I_Ca-L (IC₅₀=0.18 μM). The effects on I_Ca-L are use- and frequency-dependent. Dronedarone inhibits current carried by human ether-a-go-go gene (HERG)-expressing oocytes (analagous to I_Kr) with an IC₅₀ of 9 μM. In guinea pig ventricular myocytes, dronedarone exhibits a state dependent inhibition of the fast Na⁺ channel current with an IC₅₀ of 0.7±0.1 μM, when the holding potential is ?80 mV.

In Vivo: Dronedarone (Hydrochloride) reduces significantly the incidence of ventricular fibrillation (VF) from 80 to 30% (p < 0.05) at 3 mg/kg i.v. and eliminated VF and mortality at 10 mg/kg i.v. . Dronedarone inhibited carotid artery thrombus formation in vivo. Thrombin- and collagen-induced platelet aggregation is impaired indronedarone-treated mice (P\0.05), and expression ofplasminogen activator inhibitor-1 (PAI1), an inhibitor of the fibrinolytic system, is reduced in the arterial wall.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  FDA-Approved Drug Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Nigericin sodium salt  |  BAPTA-AM  |  Rosuvastatin Calcium  |  SKF-96365 hydrochloride  |  Glibenclamide  |  SCH-23390 hydrochloride  |  Tetrandrine  |  Amiodarone hydrochloride  |  TRAM-34  |  Ifenprodil tartrate  |  Minoxidil  |  Diazoxide  |  20(S)-Ginsenoside Rg3  |  Senicapoc  |  Tannic acid  |  DCPIB  |  Astemizole  |  Ketanserin  |  Quinine  |  E-4031  |  Terfenadine  |  Hydrochlorothiazide  |  GW9508  |  Daurisoline  |  Nicorandil  |  Dofetilide  |  Pinacidil monohydrate  |  ML277  |  Tolbutamide  |  Almitrine mesylate

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。