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Gemcitabine hydrochloride
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Gemcitabine hydrochloride
CAS No. : 122111-03-9
MCE 站:Gemcitabine hydrochloride
产品活性:Gemcitabine Hydrochloride (LY 188011 Hydrochloride) 是一种嘧啶核苷类似物抗代谢药 (nucleoside antimetabolite/analog) 和抗肿瘤剂。Gemcitabine 抑制 DNA 合成 (DNA synthesis) 和修复,导致细胞自噬 (autophagy) 和凋亡 (apoptosis)。
研究领域:Cell Cycle/DNA Damage | Autophagy | Apoptosis
作用靶点:DNA/RNA Synthesis | Nucleoside Antimetabolite/Analog | Autophagy | Apoptosis
In Vitro: Gemcitabine Hydrochloride (purchased from MedChem Express, 0.003-1 μM; 3 days) kills both mouse and human senescent cells effectively and potently.
Gemcitabine Hydrochloride inhibits the growth of BxPC-3, Mia Paca-2, PANC-1, PL-45 and AsPC-1 cells with IC50s of 37.6, 42.9, 92.7, 89.3 and 131.4 nM, respectively.
In Vivo: Gemcitabine Hydrochloride can be administered via endotracheal spray in rats without marked toxicity with a maximum tolerated dose of 4 mg/kg once a week for 9 weeks. The toxicity of Gemcitabine is lower via lung than oral administration at dosages of 2, 4, and 6 mg/kg.
Treatment of the LSL-KrasG12D/+; LSL-Trp53R172H; Pdx-1-Cre mice with either Gemcitabine (50 mg/kg, i.p.) or the combination DMAPT/Gemcitabine Hydrochloride significantly increases the median survival time by more than 30 days compared to the placebo group (254.5 or 255 days vs. 217.5 days, respectively).
相关产品:Natural Product Like Compound Library | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Reprogramming Compound Library | Nucleotide Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | FDA Approved & Pharmacopeial Drug Library | Drug-Induced Liver Injury (DILI) Compound Library | Anti-Blood Cancer Compound Library | MG-132 | LY294002 | Doxorubicin hydrochloride | Bafilomycin A1 | Paclitaxel | Cycloheximide | Y-27632 dihydrochloride | Acetylcysteine | Angiotensin II human | SP600125 | 5-Fluorouracil | Staurosporine | Bortezomib | Tamoxifen | 2-Deoxy-D-glucose | Oxaliplatin | Gemcitabine | Verteporfin | Decitabine | Actinomycin D | Temozolomide | 5-Azacytidine | BAY 11-7082 | Etoposide | Mitomycin C | CCCP | DAPT | Rote | Etomoxir
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