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5-Azacytidine

CAS No. : 320-67-2

MCE 站：5-Azacytidine

产品活性：5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) 是胞苷核苷类似物，特异型抑制 DNA 甲基化。5-Azacytidine 与 DNA 结合共价捕获 DNA甲基转移酶 (DNA methyltransferases)，有益于逆转表观遗传变化。5-Azacytidine 诱导细胞自噬 (autophagy)。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Anti-infection  |  Autophagy

作用靶点：Nucleoside Antimetabolite/Analog  |  DNA Methyltransferase  |  Bacterial  |  Autophagy  |  Antibiotic

In Vitro: Unmethylated CpG islands associated with a variety of genes become partially or fully methylated in tumors and can be reactivated by 5-Azacytidine. 5-Azacytidine acts as weak inducers of erythroid differentiation of Friend erythroleukemia cells in the same concentration range where they affect DNA methyltransferase activity. 5-Azacytidine inhibits L1210 cells with ID₅₀ and ID₉₀ values of 0.019 and circa 0.15 μg/mL, respectively.

In Vivo: TdR-³H incorporation is significantly inhibited when the animals are exposed to 5-Azacitidine (100 mg/kg, i.p.) for 2 hr or longer.

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