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XMD17-109

CAS No. : 1435488-37-1

MCE 站：XMD17-109

产品活性：XMD17-109 是一种特异性的 ERK-5 抑制剂，IC₅₀ 值为 162 nM。

研究领域：MAPK/ERK Pathway  |  Stem Cell/Wnt

作用靶点：ERK

In Vitro: XMD17-109 (Compound 26) inhibits ERK5 biochemically with an IC₅₀ of 0.162 ± 0.006 μM, and blocks pidermal growth factor induced ERK5 autophosphorylation with an EC₅₀ of 0.09 ± 0.03 μM in cells. XMD17-109 also inhibits LRRK2[G2019S] with an IC₅₀ of 339 nM. XMD17-109 demonstrats low nanomolar cellular activity judged by the significant dose-dependent reduction of mobility shifted phosphorylated ERK5 bands from sorbitol stimulated cells. XMD17-109 completely inhibits the ERK5-mediated AP1 transcriptional activity at 30 μM and has an EC₅₀ of 4.2 μM.

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