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KN-93 hydrochloride

CAS No. : 1956426-56-4

MCE 站：KN-93 hydrochloride

产品活性：KN-93 hydrochloride是可渗透细胞，可逆和竞争性的抑制剂钙调蛋白依赖性激酶II型 (CaMKII) 抑制剂，K_i 为370 nM。

研究领域：Neuronal Signaling  |  Autophagy

作用靶点：CaMK  |  Autophagy

In Vitro: After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H⁺, K⁺-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca²⁺-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Neuronal Signaling Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  KN-93  |  STO-609  |  K-252a  |  KN-62  |  A-484954  |  NH125  |  Calmidazolium chloride  |  W-7 hydrochloride  |  MLCK inhibitor peptide 18  |  CaMKII-IN-1  |  Autocamtide-2-related inhibitory peptide TFA  |  Syntide 2 TFA  |  Rimacalib  |  A-3 hydrochloride  |  Autocamtide 2  |  Calmodulin-Dependent Protein Kinase II(290-309) acetate  |  Autocamtide-2-related inhibitory peptide, myristoylated  |  Lavendustin C  |  Psoralenoside  |  Autocamtide 2, amide  |  Metofenazate

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