MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Risperidone

CAS No. : 106266-06-2

MCE 站：Risperidone

产品活性：Risperidone是 5-HT₂ 受体的阻断剂，P-糖蛋白 (P-Glycoprotein) 的抑制剂 和 dopamine D₂ 受体的拮抗剂，其对 5-HT_2A 和 dopamine D₂ 受体的 K_i 值分别为 4.8，5.9 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Membrane Transporter/Ion Channel

作用靶点：5-HT Receptor  |  Dopamine Receptor  |  P-glycoprotein

In Vitro: Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively. Risperidone dose-dependently inhibited the release of IL-12 in mature DCs, while the production of IL-10 is dose-dependently increased by Risperidone. A high dose of risperidone can induce TNF-α release from mature DCs.

In Vivo: In the first experiment, body weight is found to be slightly but significantly lower in the Risperidone-treated rats as a function of age. Similar to the first experiment, age-dependent differences in body weight are also observed between the three treatment groups in the second locomotor experiment. Rats treated with the 3.0 mg/kg dose of Risperidone weigh less than vehicle-treated rats on postnatal days 35, 38, and 41. The third locomotor experiment involves larger, mixed-sex litters in contrast to the smaller, single-sex litters used in the first two experiments. As noted for the first two experiments, rats treated with Risperidone in the third experiment gain less weight in an age-dependent manner.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Neuronal Signaling Compound Library  |  FDA-Approved Drug Library  |  CNS-Penetrant Compound Library  |  Drug Repurposing Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Alzheimer’s Disease Compound Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Clozapine N-oxide  |  MPTP hydrochloride  |  Verapamil hydrochloride  |  Oxidopamine hydrobromide  |  Elacridar  |  Bromocriptine mesylate  |  Harmine  |  SCH-23390 hydrochloride  |  Pimozide  |  L-DOPA  |  Tariquidar  |  Puerarin  |  Olanzapine  |  Haloperidol  |  GTS-21 dihydrochloride  |  Valspodar  |  Thioridazine hydrochloride  |  Atazanavir sulfate  |  SKF 38393 hydrochloride  |  Cabergoline  |  SB-269970 hydrochloride  |  Fluphenazine dihydrochloride  |  Dihydroergotamine mesylate  |  Zosuquidar trihydrochloride  |  Amitriptyline hydrochloride  |  Aripiprazole  |  Ketanserin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。