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Troglitazone

CAS No. : 97322-87-7

MCE 站：Troglitazone

产品活性：Troglitazone 是 PPARγ 的激动剂，对人和鼠 PPARγ的 EC₅₀ 值分别为 550 nM 和 780 nM。

研究领域：Cell Cycle/DNA Damage  |  Autophagy  |  Apoptosis

作用靶点：PPAR  |  Autophagy  |  Apoptosis  |  Ferroptosis

In Vitro: Troglitazone is a PPARγ agonist, with EC₅₀s of 550 nM and 780 nM for human and murine?PPARγ receptor, respectively. Troglitazone (2-200 μM) is cytotoxic to the pancreatic cancer cell lines (MIA Paca2 and PANC-1 cells), with IC₅₀s of 49.9?±?1.2 and 51.3?±?5.3 μM, respectively. Troglitazone (50 μM) increases chromatin condensation in MIA Paca2 and PANC-1 cells, enhances the activity of caspase-3 and decreases Bcl-2 expression. Troglitazone (0, 1, 2, and 4 μM) sensitizes TRAIL-mediated apoptosis in human lung adenocarcinoma cells. Troglitazone enhancement of TRAIL-induced apoptosis is blocked by inhibition of autophagy, via activation of autophagy flux. In addition, the effects of troglitazone are induced by PPARγ activation in A549 cells.

In Vivo: Troglitazone (200 mg/kg, p.o.) shows inhibitory effects on the growth of tumor in the MIA Paca2 xenograft model.

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