MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

SR-3677

CAS No. : 1072959-67-1

MCE 站：SR-3677

产品活性：SR-3677是高效的选择性的ROCK-II抑制剂，IC₅₀值为~3 nM。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  Cytoskeleton  |  TGF-beta/Smad  |  Autophagy

作用靶点：ROCK  |  Autophagy

In Vitro: SR-3677 has an IC₅₀ of ~3 nM in enzyme and cell based assays and has an off-target hit rate of 1.4% against 353 kinases, and inhibits only 3 out of 70 nonkinase enzymes and receptors. The IC₅₀ value of SR-3677 for ROCK-I is 56±12 nM. The hydrophobic interaction of the benzodioxane phenyl ring with the hydrophobic surface of the pocket is the dominating factor that contributes to the high potency of SR-3677.

In Vivo: ExVivo: Pharmacology studies shows that SR-3677 is efficacious in both, increasing ex vivoaqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation. Continuous exposure of 25 ?M SR-3677 increases the outflow facility by 60% at 1 h perfusion, increasing to 70–80% for the 2–5 h time points.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Stem Cell Signaling Compound Library  |  TGF-beta/Smad Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Cytoskeleton Compound Library  |  Y-27632 dihydrochloride  |  Chroman 1  |  Fasudil Hydrochloride  |  Narciclasine  |  Ripasudil  |  GSK429286A  |  Y-33075  |  CMPD101  |  H-1152 dihydrochloride  |  Hydroxyfasudil  |  BDP5290  |  SB-772077B dihydrochloride  |  Pentanoic acid  |  ZINC00881524  |  Verosudil  |  ROCK-IN-1  |  ROCK2-IN-2

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。