MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Amisulpride hydrochloride

CAS No. : 81342-13-4

MCE 站：Amisulpride hydrochloride

产品活性：Amisulpride hydrochloride 是一种多巴胺 D₂/D₃ 受体拮抗剂，对于人多巴胺 D₂ 和 D₃ 的 K_i 值分别为 2.8 和 3.2 nM。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Dopamine Receptor

In Vitro: Amisulpride hydrochloride is an atypical dopamine D₂/D₃ receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D₂ and D₃, respectively. Amisulpride hydrochloride (100 nM) inhibits quinpirole-elicited [³H]thymidine incorporation with an IC₅₀ value of 22±3 nM (n=3). Amisulpride hydrochloride slightly but significantly increases [³H]dopamine release from slices of the rat striatum (S₂/S₁=0.88±0.04 under control conditions, n=6; 1.04±0.08 in the presence of 100 nM Amisulpride hydrochloride,n=4; P<0.05) and opposes the inhibitory effects of 7-OH-DPAT in both brain areas.

In Vivo: Only the highest dose of Amisulpride hydrochloride (100 mg/kg) significantly reduces dopamine levels in the striatum or limbic system. Amisulpride hydrochloride significantly increases the synthesis of dopamine in the rat striatum and limbic system at doses of 20 and 100 mg/kg. Amisulpride hydrochloride (0.5 to 75 mg/kg) fails to provoke an additional increase in dopa accumulation in the striatum but slightly accelerates, at 75 mg/kg, dopamine synthesis in the limbic system. In comparison with vehicle-treated controls, Amisulpride hydrochloride (10 mg/kg) increases extracellular dopamine levels. The administration of Amisulpride hydrochloride (0.5 to 15 mg/kg s.c.) provokes a time- and dose-dependent increase in the stimulation-evoked dopamine release. Amisulpride hydrochloride decreases striatal ACh levels significantly at 30 and 100 mg/kg (87.5% and 56.3% of control levels, respectively). In both acute study, Amisulpride hydrochloride (70 mg/kg, p.o.) significantly increases the duration of swimming behavior [F(3,28)=45.90, p<0.01].

相关产品：Clozapine N-oxide  |  MPTP hydrochloride  |  Oxidopamine hydrobromide  |  Bromocriptine mesylate  |  SCH-23390 hydrochloride  |  Pimozide  |  L-DOPA  |  Olanzapine  |  Haloperidol  |  Thioridazine hydrochloride  |  Risperidone  |  SKF 38393 hydrochloride  |  Cabergoline  |  Fluphenazine dihydrochloride  |  WAY-100635 Maleate  |  Clomipramine hydrochloride  |  Quetiapine  |  Domperidone  |  Lumateperone tosylate  |  Perphenazine  |  Sulpiride  |  Fenoldopam mesylate  |  Levomepromazine  |  Ziprasidone  |  Paliperidone  |  Sertindole  |  Chlorprothixene

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。