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Metformin hydrochloride
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Metformin hydrochloride
CAS No. : 1115-70-4
MCE 站:Metformin hydrochloride
产品活性:Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) 抑制肝脏中的线粒体呼吸链,导致 AMPK 活化,增强胰岛素敏感性,可用于 2 型糖尿病的研究。Metformin hydrochloride 可以透过血脑屏障,诱导自噬 (autophagy)。
研究领域:Epigenetics | PI3K/Akt/mTOR | Autophagy
作用靶点:AMPK | Autophagy | Mitophagy
In Vitro: Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits proliferation of ESCs in a concentration-dependent manner. The IC50 is 2.45?mM for A-ESCs and 7.87?mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase.
Metformin hydrochloride (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC50 value of 196.5 μM in cultured rat hepatocytes.
Metformin hydrochloride shows cell viability and cytotoxic effects on PC-3 cells with IC50 of 5 mM.
In Vivo: Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with NSC 37745 groups attenuates myocyte necrosis through histopathological analysis.
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