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Pitavastatin Calcium

CAS No. : 147526-32-7

MCE 站：Pitavastatin Calcium

产品活性：Pitavastatin Calcium (NK-104 hemicalcium) 是有效的羟甲基戊二酰-CoA (HMG-CoA) 还原酶抑制剂。Pitavastatin Calcium 在 HepG2 细胞中抑制乙酸合成胆固醇的 IC₅₀ 为 5.8 nM。Pitavastatin Calcium 是一种高效的肝细胞低密度脂蛋白胆固醇 (LDL-C) 受体诱导剂。具有抗癌活性。

研究领域：Metabolic Enzyme/Protease  |  Autophagy  |  Apoptosis

作用靶点：HMG-CoA Reductase (HMGCR)  |  Autophagy  |  Mitophagy  |  Apoptosis

In Vitro: Pitavastatin Calcium inhibits the growth of a panel of ovarian cancer cells, including those considered most likely to represent HGSOC, grown as a monolayers (IC₅₀?=?0.4-5?μM) or as spheroids (IC₅₀=0.6-4?μM).
Pitavastatin Calcium (1 μM; 48 hours ) induces apoptosis, evidenced by the increased activity of executioner caspases-3,7 as well as caspase-8 and caspase-9 in?Ovcar-8 cells and Ovcar-3 cells.
Pitavastatin (1?μM, 48?hours) caused PARP cleavage in Ovcar-8 cells.

In Vivo: Pitavastatin Calcium (59?mg/kg; p.o.; twice daily for 28 days) caused significant tumour regression.

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