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Tenovin-6

CAS No. : 1011557-82-6

MCE 站：Tenovin-6

产品活性：Tenovin-6 是 Tenovin-1 (HY-13423) 的类似物，是一种 p53 转录活性的激活剂。Tenovin-6 Hydrochloride 抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC₅₀ 分别为 21 μM、10 μM 和 67 μM。Tenovin-6 也能抑制二氢乳清酸脱氢酶 (DHODH)。

研究领域：Apoptosis  |  Metabolic Enzyme/Protease  |  Cell Cycle/DNA Damage  |  Epigenetics  |  Autophagy

作用靶点：MDM-2/p53  |  Dihydroorotate Dehydrogenase  |  Sirtuin  |  Autophagy

In Vitro: Tenovin-6 inhibits the growth of S. cerevisiae cultures with an IC₅₀ of 30 μM and is more toxic to yeast than the less water-soluble tenovin-1. Tenovin-6 rapidly increases the levels of endogenous K382-Ac p53 in MCF-7 cells.
Tenovin-6 (0 to 15?μM) dose dependently increases the level of LC3-II in diverse cell types, and the increase is ATG5/7 dependent. Tenovin-6 treatment also increases the number and intensity of autophagic vesicles with or without the presence of Torin 1, and prevents Torin 1-induced SQSTM1/p62 degradation. Tenovin-6 affects the acidification of autolysosomes and impairs the hydrolytic activity of lysosomes but does not affect the fusion between autophagosomes and lysosomes. That tenovin-6 inhibits autophagy does not correlate with p53 activation and SIRT1/2 inhibition by knockdown or knockout cannot mimic the effect of tenovin-6 on LC3B accumulation.
Tenovin-6 (0, 1, 2.5, 5 or 10 μM) potently inhibits cell proliferation in a dose- and time-dependent manner in all OCI-Ly1, DHL-10, U2932, RIVA, HBL1 and OCI-Ly10 cell lines. Tenovin-6 consistently increases LC3B-II level in DLBCL cell lines by inhibiting the classical autophagy pathway, without activating p53, and the increase is independent of SIRT1/2/3 and p53. Tenovin-6 induces apoptosis through the extrinsic cell-death pathway.
Tenovin-6 suppresses the growth of UM cells with IC50 of 12.8?μM, 11.0?μM, 14.58?μM and 9.62?μM for 92.1, Mel 270, Omm 1 and Omm 2.3 cells, respectively.

In Vivo: Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice.

相关产品：Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Metabolism/Protease Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Pyroptosis Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Resveratrol  |  Selisistat  |  Nicotinamide  |  Nicotinamide riboside chloride  |  Nutlin-3a  |  Pifithrin-α hydrobromide  |  3-TYP  |  Eprenetapopt  |  Suramin sodium salt  |  OSS_128167  |  Fisetin  |  Brequinar  |  UBCS039  |  Leflunomide  |  Sirtinol  |  Amifostine  |  Pifithrin-μ  |  RITA  |  CAY10602  |  AGK2  |  MI-773  |  Pifithrin-α, p-Nitro, Cyclic  |  Vidofludimus  |  AK-7  |  SIRT5 inhibitor 1  |  Cambinol  |  MC3482

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