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Dasabuvir

CAS No. : 1132935-63-7

MCE 站：Dasabuvir

产品活性：Dasabuvir (ABT-333) 是一种非核苷抑制剂，抑制RNA依赖性的 HCV NS5B 基因编码的 RNA 聚合酶，抑制 HCV 基因型 1a 和 1b 临床分离株衍生的重组 NS5B 聚合酶，IC₅₀ 为 2.2 到 10.7 nM。

研究领域：Anti-infection

作用靶点：HCV

In Vitro: Dasabuvir (ABT-333) is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases. Dasabuvir (ABT-333) inhibits the polymerase enzymatic activity of genotype 1 laboratory strain enzymes (H77, BK, N, and Con1 strains), as well as enzymes produced from polymerase genes from HCV genotype 1-infected subjects, with IC₅₀s between 2.2 and 10.7 nM. Dasabuvir (ABT-333) inhibits replication of HCV subgenomic replicons in cell culture assays, with EC₅₀ values of 7.7 and 1.8 nM against genotype 1a (H77) and 1b (Con1), respectively. In the presence of 40% human plasma, there is a 12- to 13-fold decrease in inhibitory potency, yielding EC₅₀s of 99 and 21 nM for HCV genotype 1a (H77) and 1b (Con1) replicons, respectively.

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