MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Naveglitazar racemate

CAS No. : 916085-47-7

MCE 站：Naveglitazar racemate

产品活性：Naveglitazar racemate (LY519818 racemate) 是 Naveglitazar 的外消旋体。Naveglitazar 是过氧化物酶体增殖物激活受体 (PPAR) α-γ 双重，γ 显性激动剂，在动物模型具有降低葡萄糖潜力。

研究领域：Cell Cycle/DNA Damage

作用靶点：PPAR

In Vitro: Naveglitazar, a non-thiazolidinediones (TZD), functions as a potent and efficacious insulin sensitizer in rodents, possessing a novel profile that may result in an improved therapeutic agent for the treatment of type 2 diabetes and associated dyslipidemia. The extent of in vitro binding of [³H]Naveglitazar to plasma proteins is evaluated by ultracentrifugation in mouse, rat, and monkey plasma. The mean percentages±S.E.M. of protein binding of radioactivity in plasma over the concentration range of 0.1 to 1000 ng/ml after in vitro incubation at 37°C for 60 min are 99.5%±0.1% (mice), 99.6%±0.1% (rat), and 99.6%±0.3% (monkey). These results show that Naveglitazar is highly bound to plasma proteins among the species examined, and binding is independent of concentration.

In Vivo: [¹⁴C]Naveglitazar is quickly absorbed and moderately metabolized before elimination. After oral administration, 47, 31, and 62% of the radioactivity, as assessed by AUC values, are circulating as metabolites in mice, rats, and monkeys, respectively. Half-lives for Naveglitazar and radioactivity are similar within each species; however, monkeys have substantially longer half-lives in comparison to mice and rats. Naveglitazar and radioactivity are slowly cleared from the system circulation in all species evaluated.

相关产品：Retinoic acid  |  Rosiglitazone  |  GW9662  |  GW6471  |  Pioglitazone  |  Fenofibrate  |  T0070907  |  Troglitazone  |  Fisetin  |  GW 501516  |  Pirinixic acid  |  5-Aminosalicylic Acid  |  Daidzein  |  GW1929  |  Naringenin  |  Icariin  |  MK-886  |  GW7647  |  Bezafibrate  |  GSK3787  |  GW0742  |  Astaxanthin  |  FH535  |  Magnolol  |  Gemfibrozil  |  Seladelpar sodium salt  |  Palmitelaidic Acid  |  Eupatilin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。