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Docebe

CAS No. : 80809-81-0

MCE 站：Docebe

产品活性：Docebe (AA 861) 是一种有效的、选择性的和有口服活性的 5-脂氧合酶 (5-LO) 抑制剂。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Lipoxygenase  |  Ferroptosis

In Vitro: Treatment of trichomonads with the 5-LO inhibitor Docebe, significantly inhibits the ability of trichomonads to secrete LTB₄ compared to results for trichomonads treated with medium. Docebe strongly abolishes the stimulatory effect of TvSP on IL-8 production. Docebe at 10-200 μM increases [Ca²⁺]_i concentration dependently.

In Vivo: Docebe might protect experimental acute necrotizing pancreatitis in rats. Docebe suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10^-8-10^-5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebe, with doses of 10^-8-10^-5 M.

相关产品：Bioactive Compound Library Plus  |  Apoptosis Compound Library  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  Diabetes Related Compound Library  |  Ferroptosis Compound Library  |  Erastin  |  Ferrostatin-1  |  Cisplatin  |  Cycloheximide  |  RSL3  |  Acetylcysteine  |  Deferoxamine mesylate  |  SP600125  |  Necrostatin-1  |  Rosiglitazone  |  SB 202190  |  Curcumin  |  Hemin  |  (-)-Epigallocatechin Gallate  |  TBHQ  |  Simvastatin  |  Bardoxolone methyl  |  U-73122  |  Pifithrin-α hydrobromide  |  Lovastatin  |  Trolox  |  Eprenetapopt  |  L-Glutathione reduced  |  Pioglitazone  |  Deferiprone  |  NADPH tetrasodium salt  |  Artesunate  |  BAY 11-7085  |  iFSP1  |  Baicalein

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