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Cenisertib

CAS No. : 871357-89-0

MCE 站：Cenisertib

产品活性：Cenisertib (AS-703569) 是一种 ATP 竞争性的多激酶抑制剂，可抑制 Aurora-kinase-A/B，ABL1，AKT，STAT5, FLT3 的活性。Cenisertib 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长。Cenisertib 抑制异种移植模型中胰腺癌，乳腺癌，结肠癌，卵巢癌和肺癌以及白血病的肿瘤生长。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Protein Tyrosine Kinase/RTK  |  PI3K/Akt/mTOR  |  Stem Cell/Wnt  |  JAK/STAT Signaling

作用靶点：Aurora Kinase  |  Bcr-Abl  |  Akt  |  STAT  |  FLT3

In Vitro: Cenisertib (AS-703569) (1-1000 nM; for 48 hours) induces dose-dependent inhibition of proliferation in primary neoplastic mast cells (MC) .
Cenisertib (5-100 nM; for 24 hours) induces a substantial G2/M cell cycle arrest at low nanomolar concentrations in all MC lines.
Cenisertib (1-1000 nM; for 24 hours)induces apoptosis in HMC-1.1, HMC-1.2, C2, and NI-1 cells in a dose-dependent manner.
Cenisertib (5-500 nM; for 24 hours) induces cleavage of caspase 3 in both HMC-1 sub-clones as well as in C2 and NI-1 cells.

In Vivo: Cenisertib (AS-703569) (orally; 7 or 10 mg/kg/day; for 3 days followed by a 4-day rest period; for 4 weeks) significantly suppresses tumor growth.

相关产品：Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  JAK/STAT Compound Library  |  Kinase Inhibitor Library  |  PI3K/Akt/mTOR Compound Library  |  Protein Tyrosine Kinase Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Oxygen Sensing Compound Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Stattic  |  Nocodazole  |  AG490  |  Imatinib  |  Fludarabine  |  Honokiol  |  AS1517499  |  Bosutinib  |  Niclosamide  |  Artesunate  |  GSK-690693  |  Homoharringtonine  |  TPCA-1  |  Colivelin TFA  |  Cryptotanshi  |  Artemisinin  |  Napabucasin  |  Pimozide  |  STAT5-IN-1  |  C188-9  |  Oridonin  |  Perifosine  |  Guggulsterone  |  Miransertib  |  AT9283  |  Triciribine  |  Recilisib  |  SU6656  |  Isobavachalcone

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