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Nitenpyram

CAS No. : 150824-47-8

MCE 站：Nitenpyram

产品活性：Nitenpyram 是一类新烟碱和昆虫烟碱型乙酰胆碱受体 (nAChR) 激动剂，IC₅₀ 为 14 nM。Nitenpyram 是一种口服速效杀虫剂，用于抑制猫狗等动物身上的吮吸昆虫。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：nAChR

In Vivo: Nitenpyram is administered orally (1 mg/kg) for the short-term control of fleas in dogs and cats. Fleas start to fall from the animals 30 minutes post-administration and one dose can protect animals for 1-2 days.
Since Nitenpyram is highly lipophilic, it is administered orally after the meal in order to induce bile flow to help dissolve the chemical, thereby increasing GI absorption of the drug. It is rapidly and completely absorbed from the GI tract in less than 90 minutes and is completely excreted in urine within 48 hours after oral administration to dogs and cats. Nitenpyram undergoes hydroxylation, followed by conjugation in the liver. The conjugates of Nitenpyram are excreted in the urine and Nitenpyram is not accumulated in body tissues. The plasma half-life of Nitenpyram in dogs and cats are 3 and 8 hours, respectively. It is likely that animals with liver and/or kidney problems may have longer plasma half-life of Nitenpyram.

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