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Nosiheptide
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Nosiheptide
CAS No. : 56377-79-8
MCE 站:Nosiheptide
产品活性:Nosiheptide (Multhiomycin) 是一种由 Streptomyces actuosus 产生的硫肽抗生素,可抑制细菌蛋白质的合成,并在独特的大环核上具有独特的吲哚侧环系统和区域特异性羟基,已被广泛用作动物生长的饲料添加剂。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
In Vitro: Nosiheptide exhibits extremely potent activity against all contemporary Staphylococcus aureus strains tested including multiple drug-resistant clinical isolates, with MIC values ≤ 0.25 mg/L. Nosiheptide is also highly active against Enterococcus spp and the contemporary hypervirulent BI strain of Clostridium difficile but is inactive against most Gram-negative strains tested. Time-kill analysis reveals Nosiheptide to be rapidly bactericidal against Staphylococcus aureus in a concentration- and time-dependent manner, with a nearly 2-log kill noted at 6 hours at 10X MIC. Furthermore, Nosiheptide is found to be non-cytotoxic against mammalian cells at >> 100X MIC, and its anti-Staphylococcus aureus activity is not inhibited by 20% human serum. Notably, Nosiheptide exhibits a significantly prolonged post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus compared to vancomycin.
In Vivo: Nosiheptide (20 mg/kg; intraperitoneal injection; injected at 1 and 8 h post-infection; female CD1 mice) provids significant protection against mortality. Ten out of 10 of the Nosiheptide-treated mice remains alive on day 3, while 6/10 of the controls died on day 1.
相关产品:Covalent Screening Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Covalent Screening Library | Macrocyclic Compound Library | Antibacterial Compound Library | Antibiotics Library | Rapamycin | Doxorubicin hydrochloride | Bafilomycin A1 | Puromycin dihydrochloride | Cycloheximide | Chloroquine | Staurosporine | Dexamethasone | Doxycycline (hyclate) | Actinomycin D | Cyclosporin A | G-418 disulfate | 5-Azacytidine | Etoposide | Mitomycin C | CCCP | Nigericin sodium salt | Brefeldin A | Wortmannin | Resveratrol | Tunicamycin | Bleomycin sulfate | Hygromycin B | Tacrolimus | Ionomycin | Vancomycin hydrochloride | Streptozocin | Tanespimycin | Oligomycin A
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热门标签:Multhiomycin