MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

EIDD-1931

CAS No. : 3258-02-4

MCE 站：EIDD-1931

产品活性：EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) 是一种核苷类物质，是一种有效的抗病毒试剂 (anti-virus agent)。EIDD-1931 有效抑制委内瑞拉马脑炎病毒 (VEEV)、基孔肯亚病毒 (CHIKV) 和丙型肝炎病毒 (HCV) 的复制活性。

研究领域：Anti-infection  |  Cell Cycle/DNA Damage

作用靶点：SARS-CoV  |  Enterovirus  |  HCV  |  Topoisomerase

In Vitro: Beta-d-N4-hydroxycytidine is an anti-VEEV (venezuelan equine encephalitis virus) agent with EC₅₀, EC₉₀, and EC₉₉ are 0.426, 1.036, and 2.5 μM, respectively.
Beta-d-N4-hydroxycytidine inhibits CHIKV replicon activity and the 50% effective concentration (EC₅₀) s 0.8 μM in the Huh-7–CHIKV replicon cell line. Similar results is presented with the replicon in BHK-21 cells (EC₅₀=1.8 μM).
NHC has no cytotoxicity for NHC in the Huh-7 cell culture system until up to 100 μM using MTT assays. The 50% cytotoxic concentration (CCsub>50) values for NHC are determined to be 30.6 μM, 7.7 μM, and 2.5 μM in peripheral blood mononuclear (PBM), Vero, and CEM cells, respectively.
NHC behaves as a pyrimidine analog, NHC-mediated inhibition of the CHIKV replicon can be abrogated by the addition of exogenous nucleosides, such as pyrimidines C and U, but dA, dC, dG, dU, or T has no impact on the replicon. Pyrimidines A and G contributes to replicon inhibition both in the presence and in the absence of NHC.

相关产品：Bioactive Compound Library Plus  |  Doxorubicin hydrochloride  |  Chloroquine  |  Dexamethasone  |  Etoposide  |  Resiquimod  |  Hydroxychloroquine sulfate  |  Favipiravir  |  Imatinib  |  Irinotecan  |  SN-38  |  Aloxistatin  |  Camptothecin  |  Thapsigargin  |  Imiquimod  |  Camostat mesylate  |  Ivermectin  |  Honokiol  |  Topotecan Hydrochloride  |  Epirubicin hydrochloride  |  Ribavirin  |  Auranofin  |  Daunorubicin hydrochloride  |  Exatecan mesylate  |  GRL0617  |  Suramin sodium salt  |  Deferiprone  |  Berberine chloride

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。