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Go6976
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Go6976
CAS No. : 136194-77-9
MCE 站:Go6976
产品活性:Go6976 是蛋白激酶C (PKC) 的一个抑制剂,其 IC50 值为20 nM。
研究领域:Epigenetics | TGF-beta/Smad | Anti-infection
作用靶点:PKC | Influenza Virus
In Vitro: Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor. UCN-01 is originally identified as a PKC inhibitor. Surprisingly, Go6976 is found to abrogate S and G2 arrest. Dose-response studies reveal that 30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum. Incubation of cells with UCN-01 or Go6976 alone do not decrease viability compared with control at the concentrations used. Incubation of cells with 5 ng/mL SN38 result in cytostasis, and addition of 50 nM UCN-01 or 100 nM Go6976 to arrested MDA-MB-231 cells cause a dramatic decrease in viable cell number by 96 h.
相关产品:Bioactive Compound Library Plus | Anti-Infection Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | TGF-beta/Smad Compound Library | Anti-Cancer Compound Library | Antiviral Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Cytoskeleton Compound Library | Phorbol 12-myristate 13-acetate | Acetylcysteine | Staurosporine | U0126-EtOH | Tunicamycin | Vadimezan | Ionomycin | Favipiravir | Curcumin | Camptothecin | Aprotinin | Go 6983 | Midostaurin | Oseltamivir acid | Geldanamycin | Emricasan | Rifampicin | Bisindolylmaleimide I | Fasudil Hydrochloride | Mitoxantrone | Baicalein | Mycophenolic acid | AG-1478 | AEBSF hydrochloride | α-Vitamin E | Nitazoxanide | GSK 650394 | Umifenovir hydrochloride | Rottlerin
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