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Go6976

CAS No. : 136194-77-9

MCE 站：Go6976

产品活性：Go6976 是蛋白激酶C (PKC) 的一个抑制剂，其 IC₅₀ 值为20 nM。

研究领域：Epigenetics  |  TGF-beta/Smad  |  Anti-infection

作用靶点：PKC  |  Influenza Virus

In Vitro: Go6976 is a potent inhibitor of PKC in vitro (IC₅₀ is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor. UCN-01 is originally identified as a PKC inhibitor. Surprisingly, Go6976 is found to abrogate S and G₂ arrest. Dose-response studies reveal that 30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G₂ arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G₂ arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum. Incubation of cells with UCN-01 or Go6976 alone do not decrease viability compared with control at the concentrations used. Incubation of cells with 5 ng/mL SN38 result in cytostasis, and addition of 50 nM UCN-01 or 100 nM Go6976 to arrested MDA-MB-231 cells cause a dramatic decrease in viable cell number by 96 h.

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