MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Dilazep dihydrochloride

CAS No. : 20153-98-4

MCE 站：Dilazep dihydrochloride

产品活性：Dilazep dihydrochloride 是腺苷摄取的抑制剂。Dilazep dihydrochloride 通过增强腺苷的作用而具有脑和冠状血管舒张作用。Dilazep dihydrochloride 还可抑制缺血性损伤，血小板聚集和核苷的膜转运。

研究领域：Others

作用靶点：Others

In Vitro: The uptake mechanism has been studied extensively in vitro and Dilazep, NBI and Dipyridamole have been reported to inhibit the uptake of adenosine into different cells. Of these compounds, Dilazep and NBI are almost 10 times more potent than Dipyridamole. In addition, only Dilazep is water soluble and no solubility aiding organic solvent is needed for preparing an aqueous solution.

In Vivo: After administration of Dilazep, even low doses (0.04-0.1 mg/kg/min) of exogenous adenosine significantly increases superior mesenteric arterial conductance (SMAC) and elevates arterial plasma adenosine concentration. The increased adenosine levels were highly correlated with the increased percentage of change of SMAC and values for R_max and EC₅₀ were 193.4% change of SMAC and 2.8 μM, respectively. Administration of bolus doses of 8-phenyltheophylline abolishes the ability of Dilazep to potentiate vasodilation, but did not affect isoproterenol-induced relaxation.
Dilazep inhibits the phospholipase activation in reperfused heart mitochondria and also inhibits the lipid peroxidation caused by cerebral ischemia and reperfusion. Dilazep may prevent ischemic cerebral injury due to an increase in cerebral blood flow and/or its protective effects on vascular endothelial cell membrane.

相关产品：Bioactive Compound Library Plus  |  Anti-Cardiovascular Disease Compound Library  |  Ferroptosis Compound Library  |  PEG300  |  SBE-β-CD  |  Corn oil  |  Tween 80  |  Polyethylene glycol 12-hydroxystearate  |  JC-1  |  Lipopolysaccharides  |  DTT  |  (2-Hydroxypropyl)-β-cyclodextrin  |  Methyl-β-cyclodextrin  |  CFSE  |  Digitonin  |  D-Luciferin potassium salt  |  Thiazolyl Blue  |  Biotin  |  3X FLAG peptide TFA  |  Monocrotaline  |  Nile Red  |  Auxinole  |  Tocofersolan  |  FLAG peptide  |  IPTG  |  Yoda 1  |  Cremophor EL  |  GsMTx4 TFA  |  Propidium Iodide  |  DAPI dihydrochloride  |  Calcein-AM  |  Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s)

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。