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DSR-6434

CAS No. : 1059070-10-8

MCE 站：DSR-6434

产品活性：DSR-6434 是一种有效的选择性的 Toll 样受体 7 (TLR7) 激动剂，对人和小鼠 TLR7 的 EC₅₀ 分别为 7.2 nM 和 4.6 nM。DSR-6434 具有很强的抗肿瘤作用。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation. DSR-6434 is capable of stimulating reporter gene activity only in HEK293 cells expressing hTLR7 and not in HEK293 cells expressing the structurally similar hTLR8 or hTLR9.

In Vivo: DSR-6434 treatment (Compound 20; 0.1-1 mg/kg; intravenous injection; biweekly; for 4 weeks; B6C3F1 mice) suppresses the lung metastasis significantly, 78% inhibition at 0.1 mg/kg dosing (with no tumor metastasis at the 1 mg/kg group).

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