MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CKI-7 free base

CAS No. : 120615-25-0

MCE 站：CKI-7 free base

产品活性：CKI-7 free base 是一种有效且 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂，IC₅₀ 为 6 μM，K_i 为 8.5 μM。CKI-7 free base 选择性抑制 Cdc7 激酶，还抑制 SGK，S6K1 以及 MSK1。CKI-7 free base 对酪蛋白激酶 II 和其他蛋白激酶的作用弱得多。

研究领域：Cell Cycle/DNA Damage  |  Stem Cell/Wnt  |  Metabolic Enzyme/Protease  |  MAPK/ERK Pathway

作用靶点：Casein Kinase  |  CDK  |  SGK  |  Ribosomal S6 Kinase (RSK)

In Vitro: CKI-7 (0.1-10 μM; 5 days; ES cells) treatment significantly increases the expression of the early neuroectodermal marker Sox1 and the number of cells positive for the neural markers nestin and βIII-tubulin, in a concentration-dependent manner.
CKI-7 (5 μM; 5 days; ES cells) treatment suppresses SFEB-induced β-catenin stabilization on day 5, indicating that CKI-7 inhibits Wnt signaling.

In Vivo: In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  MAPK Compound Library  |  Metabolism/Protease Compound Library  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  LY294002  |  Ro-3306  |  Seliciclib  |  Flavopiridol  |  IWP-2  |  NVP-2  |  Emodin  |  GSK 650394  |  PF-4708671  |  SNS-032  |  D4476  |  AZD-5438  |  Ellagic acid  |  Kenpaullone  |  TBB  |  GSK 3 Inhibitor IX  |  AUZ 454  |  XL413 hydrochloride  |  CGP60474  |  Wogonin  |  TAK-715  |  DMAT  |  PF-670462  |  Carnosol  |  CVT-313  |  NG 52  |  BMS-265246  |  Pluripotin  |  (R)-CR8 trihydrochloride

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。