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Carprofen

CAS No. : 53716-49-7

MCE 站：Carprofen

产品活性：Carprofen 是一种非甾体类抗炎剂，为多靶点 FAAH/COX 抑制剂，能够抑制 COX-2，COX-1 和 FAAH 的活性，IC₅₀ 值分别为 3.9 μM，22.3 μM 和 78.6 μM。

研究领域：Immunology/Inflammation  |  Neuronal Signaling  |  Metabolic Enzyme/Protease  |  Autophagy

作用靶点：COX  |  FAAH  |  Autophagy

In Vitro: Carprofen (Compound 1) is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.
Carprofen (10 ?g/mL) shows cytoprotective effects in CCL and CaCL cells and decreases apoptosis of both cells. Carprofen (10 ?g/mL) exhibits nonsignificant increase in PGE2 concentration, compared with that of the respective CCL or CaCL controls.

In Vivo: Carprofen (2.2 mg/kg, p.o.) significantly decreases PGE2 concentration in blood of dogs on days 3 and 10. Carprofen also decreases amounts of gastric PGE2 synthesis on day 3, but the inhibition is not obvious on day 10. In addition, Carprofen shows no activity against gastric PGE1 synthesis in dogs on day 3 and 10.

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