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SR-31747
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SR-31747
CAS No. : 132173-07-0
MCE 站:SR-31747
产品活性:SR-31747 是一种具有免疫抑制和抗炎特性的 sigma 配体。SR-31747 通过抑制固醇异构酶来阻止细胞增殖。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Sigma Receptor
In Vitro: SR-31747 blocks the proliferation of lymphocytes at a concentration of 10 nM. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner.
In Vivo: In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition.
相关产品:Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Neuronal Signaling Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | PRE-084 hydrochloride | BD-1047 dihydrobromide | Dimemorfan phosphate | Siramesine hydrochloride | Cutamesine dihydrochloride | Blarcamesine hydrochloride | Glycerol phenylbutyrate | BD1063 dhydrochloride | Sigma-2 receptor antagonist 1 | Blonanserin | Roluperidone | Ditolylguanidine | OPC-14523 hydrochloride | Panamesine | SR-31747 free base | 4-IBP | DuP 734 | E1R | KB-5492 anhydrous | PD 144418 | (±)-Vesamicol hydrochloride
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