MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

AZD7325

CAS No. : 942437-37-8

MCE 站：AZD7325

产品活性：AZD7325 是具有口服活性的 α2,3 receptor 的正向别构调节剂 (PAM)，K_i 分别是 0.3 and 1.3 nM，但在 α1 和 α5 受体亚型上效果较差。AZD7325 是一种中等 CYP1A2 和强效 CYP3A4 诱导剂。AZD7325 具有用于焦虑和 dravet 综合征相关研究的潜力。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：GABA Receptor  |  Cytochrome P450

In Vitro: AZD7325 is a high affinity and selective modulator of the GABAA?receptor system, exhibits high binding affinity at GABAAα1,?α2?and?α3?(K_i=0.5, 0.3, and 1.3 nM, respectively), and low at GABAAα5?(K_i=230 nM).
AZD7325 (0-10 ?M; 3 consecutive days; once daily) causes a maximal CYP1A2 mRNA expression of 3.2-fold, 2.1-fold, and 2.5-fold in human hepatocytes from donor HH210, HH215, and HH216, respectively.
AZD7325 (0-10 ?M; 3 consecutive days; once daily) causes CYP1A2 and CYP3A4 protein expression in human hepatocytes from donor HH210.

In Vivo: AZD7325 (oral administration; 10, 17.8 or 31.6 mg/kg; 30 minutes before the induction of hyperthermia) attenuates hyperthermia-induced seizures, shows median thresholds in the treatment groups of 42.8°C for 10 mg/kg, 43.3°C for 17.8 mg/kg, and 43.4°C for 31.6 mg/kg compares to 42.2°C in vehicle group.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Membrane Transporter/Ion Channel Compound Library  |  Metabolism/Protease Compound Library  |  Neuronal Signaling Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Oxygen Sensing Compound Library  |  Orally Active Compound Library  |  Neurotransmitter Receptor Compound Library  |  Anti-Alzheimer’s Disease Compound Library  |  Neuroprotective Compound Library  |  Verapamil hydrochloride  |  Apigenin  |  Fenofibrate  |  (+)-Bicuculline  |  Aminooxyacetic acid hemihydrochloride  |  Ketoconazole  |  1-Aminobenzotriazole  |  Itraconazole  |  Abiraterone  |  Gabazine  |  Riluzole  |  Talarozole  |  γ-Aminobutyric acid  |  Clarithromycin  |  Picrotoxin  |  Atazanavir sulfate  |  Isavuconazole  |  Atovaquone  |  Memantine hydrochloride  |  Galangin  |  Propofol  |  Naringin  |  Vigabatrin  |  Metyrapone  |  Furafylline  |  Gemfibrozil  |  Fomepizole  |  Diosmetin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。