MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Mefentrifluconazole

CAS No. : 1417782-03-6

MCE 站：Mefentrifluconazole

产品活性：Mefentrifluconazole 是一种新型的唑类衍生物，广谱抗真菌 (antifungal agent) 剂。Mefentrifluconazole 是具有强效选择性和口服活性真菌 CYP51 的抑制剂 (K_d= 0.5 nM)，但是对人类芳香化酶 (IC₅₀=0.92 μM) 的抑制活性较小。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Fungal  |  Cytochrome P450

In Vivo: Mefentrifluconazole undergoes extensive toxicity testing, including a full program of reproductive toxicity studies. Long term repeated dose toxicity and/or carcinogenicity studies have been conducted in rats, mice, and dogs. In each species, the highest dose level investigated gives rise to systemic toxicity.
In the acute and?repeat dose toxicity studies?performed with Mefentrifluconazole. A single-dose administration to rats the LD50 is >2000?mg/kg bwt by the oral route, >5000?mg/kg bwt by the dermal route, and >5.314?mg/L by inhalation as a dust aerosol. Mefentrifluconazole is not a skin or an eye?irritant, nor is it a phototoxicant in vitro.
In the acute?neurotoxicity?study in rats, Mefentrifluconazole (oral administration; 2000?mg/kg bwt; single dose) gives rise to reduce body weight gain and transient neurobehavioral effects only on the day of treatment (unsteady gait, reduced motor activity, reduces grip strength of the forelimbs and increased distance between the hind limbs in the landing foot-splay test).
In the repeated-dose toxicity studies, the liver is the target organ in each of the three species investigated. At higher dose levels in the rat (oral diets; 383/334 mg/kg/bwt/d (4000 ppm)) and the C57BL/6JRj mouse (61 mg/kg bwt/d (300 ppm)), reduces body weight gain and food consumption, alters clinical chemistry parameters, increases liver weight and is accompanied by?liver cell hypertrophy, and/or?liver cell necrosis. At low doses, increases liver weight is not associated with any histopathological alterations and is considered to be an adaptive change to treatment.

相关产品：Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Metabolism/Protease Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Oxygen Sensing Compound Library  |  Antifungal Compound Library  |  Rapamycin  |  Ferrostatin-1  |  Cycloheximide  |  Staurosporine  |  Resveratrol  |  Tunicamycin  |  Hygromycin B  |  Oligomycin A  |  Camptothecin  |  Amphotericin B  |  Verapamil hydrochloride  |  Apigenin  |  Nystatin  |  Calcimycin  |  Fenofibrate  |  Filipin complex  |  Mycophenolic acid  |  Idarubicin hydrochloride  |  Fluconazole  |  Ketoconazole  |  1-Aminobenzotriazole  |  Itraconazole  |  Abiraterone  |  Caspofungin Acetate  |  Oligomycin  |  Posaconazole  |  Talarozole  |  Clarithromycin  |  Toyocamycin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。