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NUCC-390 dihydrochloride

CAS No. :

MCE 站：NUCC-390 dihydrochloride

产品活性：NUCC-390 dihydrochloride 是新型的选择性小分子 CXCR4 receptor 受体激动剂。NUCC-390 dihydrochloride 可以诱导 CXCR4 受体的内化，作用方式与 AMD3100 (HY-10046) 相反。NUCC-390 dihydrochloride 在动物模型中，有助于神经退行性变后神经功能恢复。

研究领域：GPCR/G Protein  |  Immunology/Inflammation

作用靶点：CXCR

In Vitro: NUCC-390 dihydrochloride (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100.
NUCC-390 dihydrochloride (10 μM; pre-treatment 30 mins) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors.
NUCC-390 dihydrochloride (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non-treated cells exhibit some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells.
NUCC-390 dihydrochloride (0-1.25 μM; 24 hours) boosts axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4.

In Vivo: NUCC-390 dihydrochloride (hind limb injection; 3.2 mg/kg; twice daily; 3 days) contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following an acute nerve terminal damage by α-LTx in CD-1 mice.

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