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PKR activator 1

CAS No. : 2283420-62-0

MCE 站：PKR activator 1

产品活性：PKR activator 1 是一种有效的丙酮酸激酶 R (PKR) 激活剂，详细信息请参考文献 WO2019035865A1 中的化合物 E7-93。

研究领域：Metabolic Enzyme/Protease

作用靶点：Pyruvate Kinase

In Vitro: Pyruvate kinase (PK) is a metabolic enzyme that converts phosphoenolpyruvate to pyruvate during glycolysis. Four PK iso forms exist in mammals: the L and R iso forms (from the PKLR gene) are expressed in liver and red blood cells respectively, and the PKM gene encodes two splice variants, the Ml isoform that is expressed in most adult tissues, and the M2 isoform that is expressed during embryonic development and in some adult tissues including the kidney and hematopoietic stem cells. Many tumor cells also express PKM2. This tetrameric allosterically regulated isoform is intrinsically designed to downregulate its activity, through post-translational modification, allosteric modulation by small molecule ligands including some amino acids, and by subunit dissociation (into the dimeric form), which results in partial inhibition of glycolysis at the last step.

相关产品：Shikonin  |  PKM2-IN-1

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