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Clozapine N-oxide dihydrochloride

CAS No. : 2250025-93-3

MCE 站：Clozapine N-oxide dihydrochloride

产品活性：Clozapine N-oxide dihydrochloride 是一种 Clozapine 的主要代谢产物，也是一种人毒蕈碱设计受体 (DREADDs) 激动剂。Clozapine N-oxide dihydrochloride 可激活 DREADD 受体 hM3Dq 和 hM4Di。Clozapine N-oxide dihydrochloride 可以穿过血脑屏障。Clozapine 是一种有效的多巴胺拮抗剂，也一种是有效的选择性毒蕈碱 M4 受体 (muscarinic M4 receptor) (EC₅₀ 为 11 nM) 激动剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Metabolic Enzyme/Protease

作用靶点：mAChR  |  Dopamine Receptor  |  Drug Metabolite

In Vitro: Clozapine N-oxide (CNO) can bind to non-DREADD receptors at concentrations required for DREADD activation, and undergoes reverse-metabolism to its parent compound clozapine, an atypical antipsychotic that acts at a variety of pharmacological targets and produces numerous physiological and behavioral effects.

In Vivo: After a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Despite the short plasma half-life of CNO in mice, the biological effects that have been described after acute treatment of DREADD-expressing experimental animals are usually much longer (6-10 h).

相关产品：Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  Metabolism/Protease Compound Library  |  Neuronal Signaling Compound Library  |  CNS-Penetrant Compound Library  |  Neurotransmitter Receptor Compound Library  |  Clozapine N-oxide  |  MPTP hydrochloride  |  Deschloroclozapine  |  Oseltamivir acid  |  Pilocarpine Hydrochloride  |  Oxidopamine hydrobromide  |  Urolithin A  |  Bromocriptine mesylate  |  Atropine  |  SCH-23390 hydrochloride  |  Pimozide  |  L-DOPA  |  Olanzapine  |  Haloperidol  |  Thioridazine hydrochloride  |  Risperidone  |  SKF 38393 hydrochloride  |  Cabergoline  |  Fluphenazine dihydrochloride  |  Amitriptyline hydrochloride  |  Levetiracetam  |  WAY-100635 Maleate  |  Clomipramine hydrochloride  |  Quetiapine  |  Domperidone  |  Carbamoylcholine chloride  |  Lumateperone tosylate  |  Perphenazine

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