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Eprazi dihydrochloride

CAS No. : 10402-53-6

MCE 站：Eprazi dihydrochloride

产品活性：Eprazi dihydrochloride 是一种具有粘液溶解，分泌分解，镇咳和支气管解痉性质的药物。Eprazi dihydrochloride 是一种神经激肽 1 受体 (NK1R) 的配体。Eprazi dihydrochloride 可用于慢性支气管炎的研究，可改善肺功能和动脉血氧分压。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Neurokinin Receptor

In Vitro: Eprazi specifically displaces binding to the NK1R. Although Eprazi displays a rather weak inhibition of [¹²⁵I]BH-SP binding to NK1R, at a concentration of 25 μM, and an antagonistic effect of about 30%, NK1R blockade could contribute to its mucolytic activity.

In Vivo: Eprazi (50-200 mg/kg; oral gavage; daily; for 4 days; adult male rats) at a dose of 200 mg/kg significantly increases total and individual (with the exception of phosphatidylinositol) phospholipid levels and decreases total neutral lipids. Lower doses of Eprazi significantly decrease neutral lipid levels without affecting the phospholipids.
In airway epithelial studies, mucosal addition of Eprazi produces a dose-dependent partially reversible decrease in short-circuit current (Isc). The decrease in Isc at lower Eprazi concentrations is accounted for entirely by a decrease in net chloride secretion while at higher concentrations both sodium and chloride transport are affected.

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