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Lipoxamycin hemisulfate

CAS No. : 11075-87-9

MCE 站：Lipoxamycin hemisulfate

产品活性：Lipoxamycin hemisulfate 是一种抗真菌抗生素，也是一种有效的丝氨酸棕榈酰转移酶 (serine palmitoyltransferase) 抑制剂，IC₅₀ 为 21 nM。

研究领域：Anti-infection

作用靶点：Fungal

In Vitro: Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the Candida species (MIC values, 0.25-16 ?g/mL). Cryptococcus neoformans is the most sensitive organism, followed by various species of Candida. Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays.
Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme.

In Vivo: Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells.

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