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Atosiban acetate

CAS No. : 914453-95-5

MCE 站：Atosiban acetate

产品活性：Atosiban acetate (RW22164 acetate;RWJ22164 acetate) 是一种九肽，竞争性的加压素/催产素受体 (vasopressin/oxytocin receptor) 拮抗剂，也是一种脱氨基催产素类似物。Atosiban acetate 是一种主要的宫缩抑制剂，可用于自发早产的研究。

研究领域：GPCR/G Protein

作用靶点：Oxytocin Receptor  |  Vasopressin Receptor

In Vitro: Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca²⁺ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua.

In Vivo: The posterior pituitary hormones, oxytocin and arginine vasopressin, differ in structure by only two amino acids, and Atosiban influences physiological effects of arginine vasopressin on the feto-maternal cardiovascular and renal systems. In late-gestation sheep, the administration of Atosiban for 1 hour fails to induce fetomaternal cardiovascular changes.
Atosiban blocks the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  GPCR/G Protein Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Drug Repurposing Compound Library  |  Macrocyclic Compound Library  |  Endocrinology Compound Library  |  NMPA-Approved Drug Library  |  FDA Approved & Pharmacopeial Drug Library  |  Oxytocin acetate  |  Argipressin  |  L-368,899 hydrochloride  |  Conivaptan hydrochloride  |  Carbetocin  |  Atosiban  |  Tolvaptan  |  Felypressin  |  LIT-001  |  Lixivaptan  |  Terlipressin acetate  |  Mozavaptan  |  Fuscoside  |  SRX246  |  Big Endothelin-1 (1-38), human  |  D[LEU4,LYS8]-VP TFA  |  L-371,257  |  SKF 100398  |  WAY-151932  |  Antagonist G  |  Big Endothelin-1 (1-39), porcine  |  d[Cha4]-AVP  |  [Asp5]-Oxytocin

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