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Enalaprilat dihydrate

CAS No. : 84680-54-6

MCE 站：Enalaprilat dihydrate

产品活性：Enalaprilat dihydrate (MK-422) 是血管紧张素转化酶 (ACE) 抑制剂，IC₅₀ 为 1.94 nM。

研究领域：Metabolic Enzyme/Protease  |  Autophagy

作用靶点：Angiotensin-converting Enzyme (ACE)  |  Autophagy

In Vitro: Enalaprilat has high affinity for human endothelial ACE with IC₅₀ of 1.94 nM in vitro binding assay by displacing a saturating concentration of [¹²⁵I]351A, a radiolabeled lisinopril analogue from ACE binding sites, and shows bradykinin/angiotensin I selectivity ratio of 1.00 calculated from double displacement experiments. Enalaprilat attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with IC₅₀ of 90 mM.

In Vivo: Administration of Enalaprilat induces a significant reduction of MAP at 70 minutes compared with the placebo group during haemorrhagic shock in rats, and results in a 50% reduction of CO, a general tendency of EB extravasation which is significant in the kidney and lungs, and a significant increase in ileal EB extravasation (53%).

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  FDA-Approved Drug Library  |  Autophagy Compound Library  |  Peptidomimetic Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  MLN-4760  |  Angiotensin (1-7)  |  Captopril  |  Enalapril maleate  |  Diminazene aceturate  |  Lisinopril dihydrate  |  Perindopril erbumine  |  Fosinopril sodium  |  Sinapinic acid  |  Benazepril hydrochloride  |  Omapatrilat  |  Quinapril hydrochloride  |  Ramipril  |  Moexipril hydrochloride  |  Phosphoramidon Disodium  |  Deserpidine  |  Cilazapril monohydrate  |  Resorcinolnaphthalein  |  Trandolapril  |  Delapril hydrochloride  |  Imidapril hydrochloride  |  Zofenopril calcium  |  H-Ile-Pro-Pro-OH hydrochloride  |  Alamandine  |  N-Acetyl-Ser-Asp-Lys-Pro TFA  |  Temocapril hydrochloride  |  BML-111

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