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Roxatidine Acetate Hydrochloride

CAS No. : 93793-83-0

MCE 站：Roxatidine Acetate Hydrochloride

产品活性：Roxatidine?Acetate Hydrochloride 是一种选择性组胺 H2 受体 (histamine H₂ receptor) 拮抗剂，可用于胃溃疡和十二指肠溃疡的研究。Roxatidine?Acetate Hydrochloride 通过酯酶在小肠，血浆和肝脏迅速转化为其活性代谢物罗沙替丁。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Histamine Receptor

In Vitro: Roxatidine Acetate Hydrochloride (6.25 ?μM, 12.5?μM, and 25?μM; pre-treatment for 30?min) suppresses the PMACI-induced activation of p38 MAPK, but does not affect the phosphorylation of ERK or JNK. The total ERK 1/2, JNK, and p38 MAPK levels are unaffected by roxatidine in?human mast-cells-1 (HMC-1)?cells.

In Vivo: Roxatidine Acetate Hydrochloride (oral gavage; 20?mg/kg; single dose) inhibits Compound 48/80-increased TNF-α, IL-6, and IL-1β production and mRNA expression. Additionally, Roxatidine decreases the compound 48/80-induced degradation of procaspase-1 and appearance of the corresponding cleaved bands in mice.

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