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Cromolyn sodium
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Cromolyn sodium
CAS No. : 15826-37-6
MCE 站:Cromolyn sodium
产品活性:Cromolyn sodium (Disodium Cromoglycate; FPL-670) 是抗过敏化合物。Cromolyn sodium 是一种 GSK-3β 抑制剂,IC50 为 2.0 ?M。
研究领域:Membrane Transporter/Ion Channel | Neuronal Signaling | PI3K/Akt/mTOR | Stem Cell/Wnt
作用靶点:Calcium Channel | GSK-3
In Vitro: Cromolyn sodium (Disodium Cromoglycate; FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
In Vivo: Pretreatment of IIR mice with Cromolyn sodium (Disodium Cromoglycate; FPL-670) prior to ischemia exhibited no changes of ET-1 levels, injury score and inflammation (P>0.05, PreCr vs. M groups). In conclusion, administration of Cromolyn (sodium) after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressing sustained MC activation. Cromolyn (sodium) has a role in the prevention of Chronic lung disease(CLD). Cromolyn (sodium) cannot be recommended for the prevention of CLD in preterm infants.
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