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Dexmedetomidine hydrochloride

CAS No. : 145108-58-3

MCE 站：Dexmedetomidine hydrochloride

产品活性：Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) 是一种有效，选择性和具有口服活性的 α2 肾上腺素能受体 (α2-adrenoceptor) 激动剂，K_i 值为 1.08 nM。Dexmedetomidine hydrochloride 对 α1 肾上腺素受体显示出 1620 倍的选择性。Dexmedetomidine hydrochloride 具有抗焦虑，镇静和适度的镇痛作用。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: Medetomidine has high selectivity for α2 adrenoceptors (K_i=1.08 nM) over α1 adrenoceptors (K_i=1750 nM) in rat brain membranes as measured by the displacement of [³H]clonidine.
Medetomidine (0.1-100 nM) inhibits the twitch response in field-stimulated mouse vas deferens, with a pD₂ of 9.0.

In Vivo: Medetomidine (10-100 μg/kg; i.v. at 5-min intervals) produces a dose-dependent pupillary dilatation in pentobarbitone-anaesthetized rats.

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