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Propranolol hydrochloride

CAS No. : 318-98-9

MCE 站：Propranolol hydrochloride

产品活性：Propranolol hydrochloride 是一种非选择性的 β-adrenergic receptor (βAR) 拮抗剂，对 β1AR 和 β2AR 具有高亲和力，K_i 值分别为 1.8 nM 和 0.8 nM。Propranolol hydrochloride 抑制 [³H]-DHA 与大鼠脑膜制剂的结合，IC₅₀ 为 12 nM。Propranolol hydrochloride 可以用于高血压，嗜铬细胞瘤，心肌梗塞，心律不齐，心绞痛和肥大心肌病的相关研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Adrenergic Receptor

In Vitro: Propranolol hydrochloride (10^-7 M-10^-3 M; 24 and 48 hours) increases the total ERK1/2 levels in a dose-dependent manner, and ERK1/2 activation is observed specifically at 10^-5 M in HemSCs.
Propranolol hydrochloride (10^-9 M-10^-3 M; 24 and 48 hours) significant decreases cell proliferation at 10^-4 M propranolol after 24 hours and 10^-9 M propranolol after 48 hours in HemSCs.
Propranolol hydrochloride (50 μM-200 μM; 24 hours) increases Annexin V positivity and caspase-3 activation, rapidly induces HemSC apoptosis.

In Vivo: Propranolol hydrochloride (orally administration; 40 mg/kg; daily) significantly reduces the vessel diameter relative to the vehicle-treated implants, and increases the number of cells that expressed phosphorylated ERK1/2 within the IH Matrigel implant.

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