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Atovaquone

CAS No. : 95233-18-4

MCE 站：Atovaquone

产品活性：Atovaquone (Atavaquone) 是一种有效的、具有口服活性的选择性寄生虫线粒体细胞色素 bc1 (parasite’s mitochondrial cytochrome?bc1) 复合物的抑制剂。Atovaquone 抑制人类和 P. falciparum?细胞色素 bc1?活性，IC₅₀ 值分别为 460 nM 和 2.0 nM。Atovaquone 是一种抗疟 (antimalarial agent) 试剂，有潜力用于肺孢子虫肺炎、弓形体病、疟疾和巴贝斯虫病的相关研究。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease

作用靶点：Parasite  |  Cytochrome P450  |  Antibiotic

In Vitro: Atovaquone targets to the Q_o?site of the?Plasmodium?cytochrome?bc1?complex of the mitochondrial electron transport chain.
Atovaquone is against the development in the mosquito from gamete production, through fertilization, zygote formation and finally, to the development of the mature ookinete, and demonstrates an IC₅₀?of 67 nM providing further evidence of the transmission blocking potential of this molecule.

In Vivo: Atovaquone (oral administration; 100 mg/kg; once daily) is against survival rates of mice, mice treated orally died within 22 days after discontinuation of sulfadiazine,while the control group died at day 14.

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