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Glasdegib

CAS No. : 1095173-27-5

MCE 站：Glasdegib

产品活性：Glasdegib (PF-04449913) 是一种有效的，具有口服活性的 smoothened 抑制剂。Glasdegib (PF-04449913) 结合到人 SMO (181-787氨基酸位点)，IC₅₀ 为 4 nM。

研究领域：Stem Cell/Wnt

作用靶点：Smo

In Vitro: Glasdegib (PF-04449913) inhibits sonic hedgehog (Shh) stimulated luciferase expression in mouse embryonic fibroblasts with an IC₅₀ of 6.8 nM; and significantly reduces medulloblastoma growth in a Ptch1^+/-p53^+/- allograft model at doses that decreased murine Shh target gene expression. In stromal co-culture experiments, FACS analysis demonstrates a significant reduction in BC LSC by Glasdegib (PF-04449913) when compared with normal progenitors. Importantly, human BC LSC engrafted RAG2^-/-γ_C^-/- mice treated daily with Glasdegib (PF-04449913) compared with vehicle treated controls have a significant spleen weight reduction (p=0.006). This reduction in leukemic burden corresponded with decreased GLI2 protein expression, as determined by both nanoproteomic analysis of FACS purified human progenitors and GLI2 confocal fluorescence microscopic analysis of splenic sections.

In Vivo: Human BC LSC engrafted RAG2^-/-γ_C^-/- mice treated daily with Glasdegib (PF-04449913) compared with vehicle treated controls had a significant spleen weight reduction (p=0.006). When CD34⁺ cord blood engrafted NSG mice are treated with Glasdegib (PF-04449913), the frequency of human CD45⁺ cells, progenitors and both myeloid and lymphoid cell fate commitment remained comparable to vehicle treated controls indicating that unlike LSC, normal human HSC cell fate decisions are Hh pathway independent. These results highlight the important niche dependent effects of selective SMO inhibition that induce GLI2 downregulation in a cell type and context specific manner.

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