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Mepivacaine hydrochloride

CAS No. : 1722-62-9

MCE 站：Mepivacaine hydrochloride

产品活性：Mepivacaine hydrochloride 是一种酰胺型药剂，具有麻醉作用。Mepivacaine hydrochloride 与神经元细胞膜上特定的电压门控钠离子通道结合，抑制钠离子内流和膜去极化。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Sodium Channel

In Vitro: Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.
Mepivacaine hydrochloride has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).
Mepivacaine hydrochloride displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels.

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