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Benztropine mesylate

CAS No. : 132-17-2

MCE 站：Benztropine mesylate

产品活性：Benztropine mesylate (Benzatropine mesylate) 是一种具有口服活性的中枢性抗胆碱能剂，可用于帕金森氏病的研究。Benztropine mesylate 是一种抗组胺剂和多巴胺再摄取 (dopamine re-uptake) 抑制剂。Benztropine mesylate 也是一种人 D₂ 多巴胺受体 (human D₂ dopamine receptor) 的变构拮抗剂，并且还具有抗癌症干细胞的作用。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation

作用靶点：Dopamine Receptor  |  mAChR  |  Histamine Receptor

In Vitro: Benztropine mesylate (0.1-10 μM; 72 hours) treatment inhibits the cell growth of MDA-MB-231 cells with an IC₅₀ of ~5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine mesylate reduces the size as well as the number of mammospheres significantly in a dose-dependent manne.
Benztropine mesylate inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors.
Benztropine mesylate induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced re-myelination.

In Vivo: Benztropine mesylate (1.5 mg/kg; daily; for 3 weeks; Balb/c mice) treatment significantly reduces both tumor size and tumor weight in a 4T1 mouse model.

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