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Atorvastatin

CAS No. : 134523-00-5

MCE 站：Atorvastatin

产品活性：Atorvastatin 是一种具有口服活性的 HMG-CoA 还原酶抑制剂，具有有效降低血脂的能力。Atorvastatin 以 IC₅₀ 值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。

研究领域：Metabolic Enzyme/Protease  |  Autophagy

作用靶点：HMG-CoA Reductase (HMGCR)  |  Autophagy

In Vitro: Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.

In Vivo: Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE^?/? mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  FDA-Approved Drug Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Ferroptosis Compound Library  |  Endoplasmic Reticulum Stress Compound Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Simvastatin  |  Lovastatin  |  Atorvastatin hemicalcium salt  |  Rosuvastatin Calcium  |  Mevastatin  |  Fluvastatin sodium  |  Pitavastatin Calcium  |  Pravastatin sodium  |  Meglutol  |  SR12813  |  Cerivastatin sodium  |  Clinofibrate  |  Hesperetin 7-O-glucoside  |  (3R,5R)-Rosuvastatin  |  (3R,5S)-Fluvastatin  |  (3S,5R)-Rosuvastatin  |  (Rac)-5-Keto Fluvastatin  |  (rel)-Atorvastatin  |  2'-Ethyl Simvastatin  |  3α-Hydroxy pravastatin sodium  |  Atorvastatin lactone

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