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Maribavir

CAS No. : 176161-24-3

MCE 站：Maribavir

产品活性：Maribavir 是一种有效抑制野生型 pUL97 催化的组蛋白磷酸化，IC₅₀ 为 3 nM。Maribavir 可有效作用于 HCMV 和 Epstein-Barr 病毒 (EBV)。

研究领域：Anti-infection

作用靶点：CMV

In Vitro: Maribavir is a potent inhibitor of the autophosporylation of the wild type and all the major Ganciclovir (GCV) resistant UL97 mutants analysed with a mean IC₅₀ of 35 nM. The M460I mutation results in hypersensitivity to Maribavir with an IC₅₀ of 4.8 nM. A Maribavir resistant mutant of UL97 (L397R) is functionally compromised as both a Ganciclovir kinase and a protein kinase (~ 10% of wild type levels). Enzyme kinetic experiments demonstrate that Maribavir is a competitive inhibitor of ATP with a K_i of 10 nM. Maribavir (1263W94) inhibits viral replication in a dose-dependent manner, with IC₅₀ of 0.12±0.01 μM as measured by a multicycle DNA hybridization assay. The pUL97 protein kinase is strongly inhibited by Maribavir, with 50% inhibition occurring at 3 nM.

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