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Bedaquiline fumarate
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Bedaquiline fumarate
CAS No. : 845533-86-0
MCE 站:Bedaquiline fumarate
产品活性:Bedaquiline fumarate 是一种二芳基喹啉抗生素,能够作用于 ATP 合成酶,常用于结核杆菌感染的研究。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
In Vitro: Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L. Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity against Mycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) seem more susceptible to bedaquiline than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species. Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis.
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