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Carmustine

CAS No. : 154-93-8

MCE 站：Carmustine

产品活性：Carmustine 是一种抗肿瘤化疗剂，为 DNA 和 RNA 的烷化剂 (alkylator)。

研究领域：Cell Cycle/DNA Damage

作用靶点：DNA Alkylator/Crosslinker

In Vitro: Carmustine is an antitumor chemotherapeutic agent. Carmustine (8, 80, and 800 ?M) decreases N-acetyltransferase (NAT) activities for 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) in rat glial tumor cytosol and intact cells. In rat glial tumor cells, the DNA-AF adduct increases, and carmustine decreases the formation of DNA-AF adduct.

In Vivo: Carmustine (BCNU; 25 mg/kg, i.p.) causes higher levels of the rhe ratio of liver weight to body weight and plasma conjugated bilirubin, and lower biliary flow, oxidised glutation levels (GSSG) and reduced glutation (GSH)/GSSG values compared with control rats.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  NMPA-Approved Drug Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Cisplatin  |  Oxaliplatin  |  Temozolomide  |  Mitomycin C  |  Carboplatin  |  Cyclophosphamide  |  Streptozocin  |  N-Nitroso-N-methylurea  |  Busulfan  |  Calicheamicin  |  Ifosfamide  |  Melphalan  |  Bendamustine hydrochloride  |  RITA  |  Lomustine  |  Thio-TEPA  |  Altretamine  |  4-Hydroperoxy cyclophosphamide  |  Duocarmycin TM  |  Procarbazine Hydrochloride  |  Phosphoramide mustard (cyclohexanamine)  |  SJG-136  |  VAL-083  |  Trioxsalen  |  Palifosfamide  |  Treosulfan  |  Chlorambucil  |  Miriplatin  |  Nimustine hydrochloride

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