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Fenofibric acid

CAS No. : 42017-89-0

MCE 站：Fenofibric acid

产品活性：Fenofibric acid 是 fenofibrate 的活性代谢物，为 PPAR 激动剂，对 PPARα，PPARγ 和 PPARδ 的 EC₅₀ 值分别为 22.4 ?M，1.47 ?M 和 1.06 ?M；Fenofibric acid 同时可抑制 COX-2 的活性，IC₅₀ 值为 48 nM。

研究领域：Cell Cycle/DNA Damage  |  Immunology/Inflammation

作用靶点：PPAR  |  COX

In Vitro: Fenofibric acid is a PPAR activitor, with EC₅₀s of 22.4 ?M, 1.47 ?M, and 1.06 ?M for PPARα, PPARγ and PPARδ, respectively. Fenofibric acid (10, 25, 50, 75, and 100 nM) dose-dependently inhibits COX-2 enzyme, with IC₅₀ of 48 nM. Fenofibric acid (500 nM) reduces abundance of AOX1 protein in HepG2 cells. Fenofibric acid (100??M) decreases JNK1/2, c-Jun, and p38 MAPK phosphorylation, and prevents the accumulation of reactive oxygen species, endoplasmic reticulum (ER) stress and disruption of blood retinal barrier (BRB) in response to the combination of high-glucose (HG) and hypoxia in ARPE-19 cells. Fenofibric acid (100??M) activates IGF-IR/Akt/ERK1/2-mediated survival signaling pathways in ARPE-19 cells under HG conditions and hypoxia.

In Vivo: Fenofibric acid (1, 5, 10 mg/kg, p.o.) shows anti-inflammatory activity in Wistar rats with acute inflammation induced by carrageenan.

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