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Bucladesine sodium
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Bucladesine sodium
CAS No. : 16980-89-5
MCE 站:Bucladesine sodium
产品活性:Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) 是一种稳定的环 AMP (cAMP) 类似物,也是一种选择性的 PKA 活化剂,可提高细胞内 cAMP 的水平。Bucladesine sodium salt 也是一种磷酸二酯 (PDE) 抑制剂。Bucladesine sodium salt 具有抗炎活性,可用于伤口愈合不良。
研究领域:Protein Tyrosine Kinase/RTK | Stem Cell/Wnt | Metabolic Enzyme/Protease
作用靶点:PKA | Phosphodiesterase (PDE)
In Vitro: Both choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) mRNA increased approximately fourfold after treatment of PC12 cells with Bucladesine (dibutyryl cyclic AMP; dbcAMP). ChAT and PKA activity are also increased by Bucladesine.
In Vivo: Intrahippocampal infusion of Bucladesine into the CA1 region (male Albino-Wistar rats) can cause an improvement in spatial memory in maze task. Bilateral infusion of 10 μM and 100 μM Bucladesine leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory). Bucladesine via activation of PKA and induction of cAMP/PKA pathway improved spatial memory retention.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Metabolism/Protease Compound Library | Protein Tyrosine Kinase Compound Library | Stem Cell Signaling Compound Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Reprogramming Compound Library | Nucleotide Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Alzheimer’s Disease Compound Library | Staurosporine | IBMX | H-89 dihydrochloride | 8-Bromo-cAMP sodium salt | Fasudil Hydrochloride | Rolipram | Sildenafil | Theophylline | Icariin | Roflumilast | Tadalafil | PF-04957325 | Milri | Dipyridamole | Bucladesine calcium | K-252a | Pentoxifylline | Cilostazol | Ibudilast | Butein | Cilomilast | Cilostamide | Metadoxine | Daphnetin | EHNA hydrochloride | Zardaverine | Vardenafil hydrochloride | Vinpocetine | W-7 hydrochloride
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