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Cefozopran

CAS No. : 113359-04-9

MCE 站：Cefozopran

产品活性：Cefozopran (SCE-2787) 是一种半合成的、非肠道的、第四代头孢菌素。Cefozopran，作为一种抗生素，具有广谱抗菌活性，能抑制大多数革兰氏阴性和革兰氏阳性菌。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Cefozopran (SCE-2787) is a fourth-generation cephalosporin that has good activity against gram-positive organisms including methicillin-susceptible staphylococci, enterococci, and viridans group streptococci; and against gram-negative organisms including hemophilus influenza. Moreover, cefozopran has comparatively good activity against enterococci and P. aeruginosa, which are refractory to other cephalosporins.

In Vivo: Cefozopran (SCE-2787) (5-80 mg/kg; s.c.; twice a day for 5 days; four-week-old ICR male mice) is effective against acute respiratory tract infections caused by Kiebsiella pneumonia DT-S. In the model of chronic respiratory tract infection caused by K. pneumoniae 27, Cefozopran (20-80 mg/kg; s.c.; twice a day for 7 days; five-week-old CBA/J female mice) is as effective as Ceftazidime.

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