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Folinic acid
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Folinic acid
CAS No. : 58-05-9
MCE 站:Folinic acid
产品活性:Folinic acid (Leucovorin) 是一种生物叶酸,通常与甲氨蝶呤 (MTX) 一起作为挽救剂服用,以降低 MTX 诱导的毒性。
研究领域:Cell Cycle/DNA Damage | Metabolic Enzyme/Protease
作用靶点:Antifolate | Endogenous Metabolite
In Vitro: MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) .
In Vivo: Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice).
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Metabolism/Protease Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Human Endogenous Metabolite Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | FDA Approved & Pharmacopeial Drug Library | Drug-Induced Liver Injury (DILI) Compound Library | Rapamycin | 3-Methyladenine | Acetylcysteine | 5-Fluorouracil | ATP | Retinoic acid | Hydrocortisone | Docetaxel | Estradiol | Melatonin | Nicotinamide | Cytarabine | Isoprenaline hydrochloride | Prostaglandin E2 | Acetaminophen | Methotrexate | (-)-Epigallocatechin Gallate | β-Nicotinamide mononucleotide | Calcitriol | DHEA | Liothyronine | NAD+ | Luteolin | Thymidine | Docosahexaenoic Acid | Pemetrexed | Kaempferol | Palmitic acid | Cyclopamine | Genistein
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